{"id":4049,"date":"2023-01-11T13:55:00","date_gmt":"2023-01-11T12:55:00","guid":{"rendered":"https:\/\/www.securetec.net\/2023\/01\/11\/newsletter-naturlicher-speichel-versus-kunstlicher-speichel\/"},"modified":"2026-06-16T10:35:03","modified_gmt":"2026-06-16T08:35:03","slug":"newsletter-natural-saliva-versus-artificial-saliva","status":"publish","type":"post","link":"https:\/\/www.securetec.net\/en\/2023\/01\/11\/newsletter-natural-saliva-versus-artificial-saliva\/","title":{"rendered":"Natural saliva versus artificial saliva"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mgq7ds1t-3f12339640eacc969b09be8790ffac31\">\n.avia-image-container.av-mgq7ds1t-3f12339640eacc969b09be8790ffac31 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mgq7ds1t-3f12339640eacc969b09be8790ffac31 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mgq7ds1t-3f12339640eacc969b09be8790ffac31 av-styling- avia-align-center  avia-builder-el-0  el_before_av_hr  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-4051 avia-img-lazy-loading-not-4051 avia_image ' src=\"https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h.jpeg\" alt='Kleines Kind spuckt im hohen Bogen Wasser ins Schwimmbecken' title=''  height=\"500\" width=\"1500\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h.jpeg 1500w, https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h-300x100.jpeg 300w, https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h-1030x343.jpeg 1030w, https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h-768x256.jpeg 768w, https:\/\/www.securetec.net\/wp-content\/uploads\/2023\/01\/Natuerlicher-Speichel_h-705x235.jpeg 705w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mgq7fh2r-2dabd2728094cb573d239c4859b9edaa\">\n#top .hr.hr-invisible.av-mgq7fh2r-2dabd2728094cb573d239c4859b9edaa{\nheight:25px;\n}\n<\/style>\n<div  class='hr av-mgq7fh2r-2dabd2728094cb573d239c4859b9edaa hr-invisible  avia-builder-el-1  el_after_av_image  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mluoo115-69c4d99768d91f50988969ccb60d852a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h1>Natural saliva versus artificial saliva<\/h1>\n<h2>Simply no substitute for saliva<\/h2>\n<p><strong>99.5% water and 0.5% dissolved enzymes, minerals and salts&nbsp;&ndash; it sounds so simple, yet human saliva is a highly complex fluid. To date, it has not been possible to produce realistic artificial saliva. This presents a challenge for laboratory verification of saliva-based drug tests.<\/strong><\/p>\n<p>Saliva counts among the most complex bodily fluids and plays an important role in many processes in the body. These range from lubrication of the mucous membranes in the mouth to the production of saliva to soften food and prepare it for digestion. As a result, its composition is versatile and variable. In addition to water, it contains various substances including around 400 different types of protein. Each person\u2019s saliva is unique and determined by their individual physical condition.<\/p>\n<p>For laboratory testing, it can be difficult to obtain sufficient quantities of natural saliva. However, time and again, research studies call for the use of a reproducible standard of saliva. This has given rise to a demand for artificial saliva.<\/p>\n<h3>Disadvantages of artificial saliva<\/h3>\n<p>To date, however, realistic saliva substitutes have never been successfully produced. The artificial alternatives are only ever a greatly simplified imitation of natural saliva and are never fully comparable to it.<\/p>\n<p>There are many different competing recipes for making artificial saliva. Some of these products are also enriched with additives that meet specific requirements, e.g., for corrosion testing of dentures. In addition, substances that don\u2019t occur in natural saliva are often added to artificial saliva to stabilise it. These can influence the physical properties of the synthetic alternative.<\/p>\n<p>Mucins are an important ingredient of both natural and synthetic saliva. These are highly complex glycoproteins that give saliva its slimy consistency. These mucins in human saliva have not yet been successfully isolated in sufficient quantities in a stable form. For this reason, mucins taken from the pancreas of various mammals are normally used in artificial saliva. In practice, when saliva tests for drugs are subjected to laboratory testing with artificial saliva, the cocktail of additives it contains usually leads to false results.<\/p>\n<h3>Real saliva is essential<\/h3>\n<p>Overall, the results obtained with saliva substitutes differ considerably and can scarcely be compared with one another. In addition, test results obtained with natural saliva are not comparable with the results of tests based on synthetic saliva due to the differences in composition. At present, there is no generally accepted standard for artificial saliva.<\/p>\n<p>Due to all these differences and uncertainties, natural saliva is almost always used in scientific studies. And it can be assumed that, in future, this will continue to be the only way to conduct testing under realistic conditions.<\/p>\n<\/div><\/section>\n<div  class='hr av-g82jd-83b065b6d70837985c8485fa31cc1e56 hr-default  avia-builder-el-3  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mgq70hbs-9dc47e015acf20dba1cff76c9d11c83e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>A mark of quality: tested with natural saliva<\/h2>\n<p>Despite the much higher cost associated with using real saliva for laboratory testing, all rapid screening drug tests are developed and tested exclusively in this way by Securetec Detektions-Systeme AG. This means that our test results meet realistic requirements and epitomise the reliability of the DrugWipe saliva test.<\/p>\n<\/div><\/section>\n<div  class='hr av-371nxt-943b01c66f283990178f02ab21b2bac5 hr-default  avia-builder-el-5  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mmta2ua1-42376c84734dd3cf113b5caf21c420ec '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>How is it that drugs are detectable in saliva?<\/h2>\n<p>Saliva is produced by three pairs of salivary glands, i.e., the parotid glands (in front of the ear), submandibular glands (below the lower jaw) and sublingual glands (under the tongue). These glands deliver saliva to the oral cavity at the upper jaw behind the molars and under the tongue at the lingual frenulum. The salivary glands are only separated from the surrounding blood vessels by a thin lining of epithelial cells. Many substances pass through this permeable membrane, including drugs and prescription medication. This means that there is a close correlation between the windows of detection for their active substances in blood and saliva.<\/p>\n<\/div><\/section>\n<div  class='hr av-706uji-92a00cea7595f59b91ee297cade5e38c hr-default  avia-builder-el-7  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mluumlgt-9530ffa69f7c605ae7f96c9e74c3b5c0 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2 style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-723 size-medium aligncenter\" src=\"https:\/\/www.securetec.net\/wp-content\/uploads\/2025\/11\/s503g-frei-300x68.png\" alt=\"Drogenschnelltest DrugWipe S 503 G\" width=\"300\" height=\"68\" srcset=\"https:\/\/www.securetec.net\/wp-content\/uploads\/2025\/11\/s503g-frei-300x68.png 300w, https:\/\/www.securetec.net\/wp-content\/uploads\/2025\/11\/s503g-frei-768x175.png 768w, https:\/\/www.securetec.net\/wp-content\/uploads\/2025\/11\/s503g-frei-705x161.png 705w, https:\/\/www.securetec.net\/wp-content\/uploads\/2025\/11\/s503g-frei.png 900w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/h2>\n<h2 style=\"text-align: center;\">DrugWipe<sup>\u00ae <\/sup>rapid screening drug tests produce impressive results thanks to their reliability&nbsp;&ndash; just ask, we\u2019re always happy to help!<\/h2>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mluuwmob-d3d55988080da931f1789212f54881a8\">\n#top .hr.hr-invisible.av-mluuwmob-d3d55988080da931f1789212f54881a8{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-mluuwmob-d3d55988080da931f1789212f54881a8 hr-invisible  avia-builder-el-9  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mluuqu8f-4c6bf32995833a88b8b63b59e3d3c18c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"font-size: 8pt;\">Reference:<\/p>\n<p style=\"font-size: 8pt;\">Spiehler et al.: Problems of Forensic Sciences, vol XLII, 2000, 160-168&nbsp;&ndash; Saliva: reflection of the body, International Journal of Infectious Diseases 14 (2010) e184&nbsp;&ndash; e188&nbsp;&ndash; Untersuchungen zur Biofilmbildung auf Prothesenbasismaterialien, Lehrstuhl f\u00fcr Zahn\u00e4rztliche Prothetik, Universit\u00e4t Regensburg, 2018&nbsp;&ndash; Einfluss von kommerziell erh\u00e4ltlichen Speichelersatzmitteln auf demineralisierten bovinen Schmelz in vitro, Dissertation, Universit\u00e4tsmedizin Berlin, 2010<\/p>\n<p style=\"font-size: 8pt;\">Images provided by:<\/p>\n<p style=\"font-size: 8pt;\">Securetec Detektions-Systeme AG; AdobeStock_105726492<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-20kcv3-fb1157b8f4b4ac8bee1de96942828add\">\n#top .hr.hr-invisible.av-20kcv3-fb1157b8f4b4ac8bee1de96942828add{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-20kcv3-fb1157b8f4b4ac8bee1de96942828add hr-invisible  avia-builder-el-11  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-mmt4nfqo-92052e20f9963c231fac36d9a5f0878e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"wpb_text_column wpb_content_element\"><div class='w3eden'><!-- WPDM Link Template: Default Template -->\n\n<div class=\"link-template-default card mb-2\">\n    <div class=\"card-body\">\n        <div class=\"media\">\n            <div class=\"mr-3 img-48\"><img decoding=\"async\" class=\"wpdm_icon\" alt=\"Icon\" src=\"https:\/\/www.securetec.net\/wp-content\/plugins\/download-manager\/assets\/file-type-icons\/pdf.svg\" \/><\/div>\n            <div class=\"media-body\">\n                <h3 class=\"package-title\"><a href='https:\/\/www.securetec.net\/en\/download\/securetec-newsletter-natural-saliva-versus-artificial-saliva\/'>Securetec Newsletter: natural saliva versus artificial saliva<\/a><\/h3>\n                <div class=\"text-muted text-small\"><i class=\"fas fa-copy\"><\/i> 1 file(s) <i class=\"fas fa-hdd ml-3\"><\/i> 558.35 KB<\/div>\n            <\/div>\n            <div class=\"ml-3\">\n                <a class='wpdm-download-link download-on-click btn btn-primary ' rel='nofollow' href='#' data-downloadurl=\"https:\/\/www.securetec.net\/en\/download\/securetec-newsletter-natural-saliva-versus-artificial-saliva\/?wpdmdl=4027&refresh=6ac51a0ec277b1791302158\">Download<\/a>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<\/div><\/div>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>Natural saliva is a complex fluid that is impossible to replicate. Learn why its 400 proteins and unique composition make natural saliva a major challenge for the laboratory verification of modern drug tests today.<\/p>\n","protected":false},"author":3,"featured_media":4050,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":""},"categories":[24],"tags":[],"class_list":["post-4049","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Newsletter: natural saliva versus artificial saliva<\/title>\n<meta name=\"description\" content=\"Natural saliva is unique and complex. Why artificial substitutes fail and how this impacts saliva-based drug tests. 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